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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RPS6KB1
All Species:
25.15
Human Site:
S452
Identified Species:
39.52
UniProt:
P23443
Number Species:
14
Phosphosite Substitution
Charge Score:
0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P23443
NP_003152.1
525
59140
S452
P
V
S
P
V
K
F
S
P
G
D
F
W
G
R
Chimpanzee
Pan troglodytes
XP_523815
451
50966
Q381
Q
S
E
E
D
V
S
Q
F
D
S
K
F
T
R
Rhesus Macaque
Macaca mulatta
XP_001109701
525
59511
S452
P
V
S
P
V
K
F
S
P
G
D
F
W
G
R
Dog
Lupus familis
XP_537702
525
59107
S452
P
V
S
P
V
K
F
S
P
G
D
F
W
G
R
Cat
Felis silvestris
Mouse
Mus musculus
Q8BSK8
525
59199
S452
P
V
S
P
V
K
F
S
P
G
D
F
W
G
R
Rat
Rattus norvegicus
P67999
525
59113
S452
P
V
S
P
V
K
F
S
P
G
D
F
W
G
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509850
482
54026
S409
P
V
S
P
V
K
F
S
P
G
D
F
W
G
R
Chicken
Gallus gallus
P18652
752
84421
E439
S
D
G
Y
V
V
K
E
A
I
G
V
G
S
Y
Frog
Xenopus laevis
P10666
629
71268
E420
T
D
V
Y
T
V
R
E
T
I
G
V
G
S
Y
Zebra Danio
Brachydanio rerio
Q6PFQ0
740
83378
T442
K
R
C
I
H
R
V
T
A
M
E
F
A
V
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V3I5
1207
137026
E1105
F
G
T
T
K
R
E
E
N
F
Y
G
F
S
K
Honey Bee
Apis mellifera
XP_395876
456
51514
V385
L
S
E
S
A
N
R
V
F
Q
G
F
T
Y
V
Nematode Worm
Caenorhab. elegans
Q21734
784
88102
N462
E
I
L
E
K
I
G
N
G
A
H
S
V
V
H
Sea Urchin
Strong. purpuratus
XP_781234
487
53968
S415
H
H
F
T
K
V
R
S
P
R
K
I
P
G
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q39030
471
53019
W400
K
W
F
K
A
I
N
W
K
K
L
E
A
R
E
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.9
94.2
99.8
N.A.
99.2
99.6
N.A.
90.2
31.9
36.8
32.2
N.A.
20.8
54.6
31.2
59
Protein Similarity:
100
85.9
95.6
100
N.A.
99.4
99.6
N.A.
90.8
46.6
52.7
46.6
N.A.
31.3
68
43.6
70.8
P-Site Identity:
100
6.6
100
100
N.A.
100
100
N.A.
100
6.6
0
6.6
N.A.
0
6.6
0
20
P-Site Similarity:
100
13.3
100
100
N.A.
100
100
N.A.
100
6.6
0
33.3
N.A.
26.6
6.6
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
36.3
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
55
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
14
0
0
0
14
7
0
0
14
0
0
% A
% Cys:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
14
0
0
7
0
0
0
0
7
40
0
0
0
0
% D
% Glu:
7
0
14
14
0
0
7
20
0
0
7
7
0
0
7
% E
% Phe:
7
0
14
0
0
0
40
0
14
7
0
54
14
0
0
% F
% Gly:
0
7
7
0
0
0
7
0
7
40
20
7
14
47
0
% G
% His:
7
7
0
0
7
0
0
0
0
0
7
0
0
0
7
% H
% Ile:
0
7
0
7
0
14
0
0
0
14
0
7
0
0
0
% I
% Lys:
14
0
0
7
20
40
7
0
7
7
7
7
0
0
14
% K
% Leu:
7
0
7
0
0
0
0
0
0
0
7
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
7
7
7
7
0
0
0
0
0
0
% N
% Pro:
40
0
0
40
0
0
0
0
47
0
0
0
7
0
0
% P
% Gln:
7
0
0
0
0
0
0
7
0
7
0
0
0
0
0
% Q
% Arg:
0
7
0
0
0
14
20
0
0
7
0
0
0
7
47
% R
% Ser:
7
14
40
7
0
0
7
47
0
0
7
7
0
20
7
% S
% Thr:
7
0
7
14
7
0
0
7
7
0
0
0
7
7
0
% T
% Val:
0
40
7
0
47
27
7
7
0
0
0
14
7
14
7
% V
% Trp:
0
7
0
0
0
0
0
7
0
0
0
0
40
0
0
% W
% Tyr:
0
0
0
14
0
0
0
0
0
0
7
0
0
7
14
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _